School of Medical Science and Technology

Aayauiva-&ana evaM p`aOVaoigakI iSaxaalaya,,,,,,

Associate Professor
B-132, IIT Campus, Kharagpur 721302
+91 - 3222 - 283578 (Office), +91 - 3222 - 283579 (Residence)
mahitosh @


Ph.D.(Jadavpur Univ.)

  • Cancer Biology
  • Signal Transduction
  • Apoptosis
  • Cell Cycle
  • Angiogenesis
  • Drug Delivery
Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M.. “Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.” . PLoS One. 2012;7(10):e46641. Epub 2012 Oct 15. doi:10.1371/journal.pone.0046641 (2012)

Das S, Dey KK, Bharti R, MaitiChoudhury S, Maiti S, Mandal M.. “PKI 166 induced redox signalling and apoptosis through activation of p53, MAP kinase and caspase pathway in epidermoid carcinoma.” . J Exp Ther Oncol. 2012;10(2):139-53. (2012)

Rajput S, Mandal M.. “Antitumor promoting potential of selected phytochemicals derived from spices: a review.” . Eur J Cancer Prev. 2012 Mar;21(2):205-15. Review. doi:10.1097/CEJ.0b013e32834a7f0c (2012)

Venkatesan P, Bhutia SK, Singh AK, Das SK, Dash R, Chaudhury K, Sarkar D, Fisher PB, Mandal M.. “AEE788 potentiates celecoxib-induced growth inhibition and apoptosis in human colon cancer cells.” . Life Sci. 2012 Oct 22;91(15-16):789-99. Epub 2012 Aug 24. doi:10.1016/j.lfs.2012.08.024 (2012)

Maiti S, Mallick SK, Bhutia SK, Behera B, Mandal M, Maiti TK.. “Antitumor effect of culinary-medicinal oyster mushroom, Pleurotus ostreatus (Jacq.: Fr.) P. Kumm., derived protein fraction on tumor-bearing mice models.” . Int J Med Mushrooms. 2011;13(5):427-40. (2011)

Ramachandran S, Mandal M.. “Induction of apoptosis of azurin synthesized from P. aeruginosa MTCC 2453 against Dalton's lymphoma ascites model.” . Biomed Pharmacother. 2011 Oct;65(7):461-6. Epub 2011 May 30. doi:10.1016/j.biopha.2011.03.006 (2011)

Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M.. “ZD6474 enhances paclitaxel antiproliferative and apoptotic effects in breast carcinoma cells.” . J Cell Physiol. 2011 Feb;226(2):375-84. doi:10.1002/jcp.22343. (2011)

Venkatesan P, Puvvada N, Dash R, Prashanth Kumar BN, Sarkar D, Azab B, Pathak A, Kundu SC, Fisher PB, Mandal M.. “The potential of celecoxib-loaded hydroxyapatite-chitosan nanocomposite for the treatment of colon cancer.” . Biomaterials. 2011 May;32(15):3794-806. doi:10.1016/j.biomaterials.2011.01.027 (2011)

Sethi K, Sarkar S, Das S, Rajput S, Mazumder A, Roy B, Patra S, Mohanty B, El-Naggar AK, Mandal M.. “Expressions of CK-19, NF-kappaB, E-cadherin, beta-catenin and EGFR as diagnostic and prognostic markers immunohistochemical analysis in thyroid carcinoma.” . J Exp Ther Oncol. 2011;9(3):187-99. (2011)

Jaganathan SK, Mondhe D, Wani ZA, Pal HC, Mandal M.. “Effect of honey and eugenol on Ehrlich ascites and solid carcinoma.” . J Biomed Biotechnol. 2010;2010:989163. Epub 2010 Mar 28. doi:10.1155/2010/989163 (2010)

Jaganathan SK, Mandal M.. “Involvement of non-protein thiols, mitochondrial dysfunction, reactive oxygen species and p53 in honey-induced apoptosis.” . Invest New Drugs. 2010 Oct;28(5):624-33. Epub 2009 Aug 25. doi:10.1007/s10637-009-9302-0 (2010)

Pal I, Mandal M.. “PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes.” . Acta Pharmacol Sin. 2012 Dec;33(12):1441-58. Epub 2012 Sep 17. doi:10.1038/aps.2012.72. (2010)

Jaganathan SK, Mandal SM, Jana SK, Das S, Mandal M.. “Studies on the phenolic profiling, anti-oxidant and cytotoxic activity of Indian honey: in vitro evaluation.” . Nat Prod Res. 2010 Sep;24(14):1295-306. doi:10.1080/14786410903184408 (2010)

Venkatesan P, Das S, Krishnan MM, Chakraborty C, Chaudhury K, Mandal M.. “Effect of AEE788 and/or Celecoxib on colon cancer cell morphology using advanced microscopic techniques.” . Micron. 2010 Apr;41(3):247-56. Epub 2009 Nov 10. doi:10.1016/j.micron.2009.10.008 (2010)

Sarkar S, Mazumdar A, Dash R, Sarkar D, Fisher PB, Mandal M.. “ZD6474, a dual tyrosine kinase inhibitor of EGFR and VEGFR-2, inhibits MAPK/ERK and AKT/PI3-K and induces apoptosis in breast cancer cells.” . Cancer Biol Ther. 2010 Apr;9(8):592-603. Epub 2010 Apr 4. (2010)

Sethi K, Sarkar S, Das S, Mohanty B, Mandal M.. “Biomarkers for the diagnosis of thyroid cancer.” . J Exp Ther Oncol. 2010;8(4):341-52. (2010)

Jaganathan SK, Mandal M.. “Antiproliferative effects of honey and of its polyphenols: a review.” . J Biomed Biotechnol. ;2009:830616. Epub 2009 Jul 19. doi:10.1155/2009/830616 (2009)

Mandal SM, Dey S, Mandal M, Sarkar S, Maria-Neto S, Franco OL.. “Identification and structural insights of three novel antimicrobial peptides isolated from green coconut water” . Peptides, 30,633-637, (2009)

Jaganathan SK and Mandal M. “Rheology and thermal properties of marketed Indian honey” . Nutrition Food Science, 39 (2):111-117, 2009. (2009)

Mandal S, Mandal M, Das A, Pati B, Ghosh A. “Stimulation of indoleacetic acid production in a Rhizobium isolate of Vigna mungo root nodule phenolic acids” . Arch Microbiol., ;191(4):389-93, 2009. (2009)

Mandal SM, Ghosh AK, Mandal M. “Iron oxide nanoparticle assisted purification and mass spectrometry based proteolytic mapping of intact CD4+ T cells from human blood.” . Prep Biochem Biotechnol., 39(1):20-31 , (2009)

Sarkar S, Mandal M.. “Growth factor receptors and apoptosis regulators: signaling pathways, prognosis, chemosensitivity and treatment outcomes of breast cancer.” . Breast Cancer: Basic and Clinical Research. 2009 Aug 17;3:47-60. (2009)

Mandal SM, Mandal M, Pati BR, Das AK, Ghosh AK. “Proteomics view of a Rhizobium isolate response to arsenite” . Acta Microbiol Immunol Hung., 56(2):157-67, 2009. (2009)

Mandal SM, Mandal M, Ghosh AK, Dey S. “Rapid determination of vitamin B2 and B12 in human urine isocratic liquid chromatography” . Anal Chim Acta, 27;640(1-2):110-3 , 2009. (2009)

Mandal M, Myers JN, Lippman SM, Johnson FM, Williams MD, Rayala S, Ohshiro K, Rosenthal DI, Weber RS, Gallick GE, El-Naggar A. “Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes” . Cancer, 112(9):2088-100, 2008. (2008)

Mandal M, Myers JN, Lippman SM, Johnson FM, Williams MD, Rayala S, Ohshiro K, Rosenthal DI, Weber RS, Gallick GE, El-Naggar AK.. “Epithelial to mesenchymal transition in head and neck squamous carcinoma: association of Src activation with E-cadherin down-regulation, vimentin expression, and aggressive tumor features.” . Cancer (2008)

Prichard CN, Kim S, Yazici YD, Doan DD, Jasser SA, Mandal M, Myers JN. “Concurrent cetuximab and bevacizumab therapy in a murine orthotopic model of anaplastic thyroid carcinoma” . Laryngoscope., 117(4):674-9, 2007. (2007)

Kupferman ME, Patel V, Sriuranpong V, Amornphimoltham P, Jasser SA, Mandal M, Zhou G, Wang J, Coombes K, Multani A, Pathak S, Silvio Gutkind J, Myers JN.. “Molecular analysis of anoikis resistance in oral cavity squamous cell carcinoma.” . 2007 May;43(5):440-54. Epub 2006 Sep 15. (2006)

Current Sponsored Projects

Project Title: DST FIST for SMST
Principal Investigator: Prof. P. K. Dutta
Co-Principal Investigator: All faculty members of SMST
Sponsor: DST, Govt. of India

Project Title: Development of Dense and Porous Titanium Components via Powder Metallurgy Route for Biomedical Applications
Principal Investigator: Dr. Santanu Dhara
Co-Principal Investigator: Dr. Mahitosh Mandal
Sponsor: DRDO, India

Project Title: Sequence Dependent Molecular Action of ZD6474 with Paclitaxel and Radiation in Progress and Treatment of Breast Cancer (PRB)
Principal Investigator: Dr. Mahitosh Mandal
Co-Principal Investigator: Dr.Santanu Dhara
Sponsor: DBT, India

Project Title: Evaluation of S100A7 (Psoriasin) as an Early Detection Marker of Squamous Cell Carcinoma.
Principal Investigator: Dr. Mahitosh Mandal
Co-Principal Investigator: Dr. Sukumar Maity
Sponsor: DST, India

Project Title: Indian Origin Silk based biomimetic scaffords for engineering of load bearing tissue
Principal Investigator: SC Kundu
Co-Principal Investigator: M Mandal, A Mukhopadhyay ( NII, New Delhi)
Sponsor: Dept of Biotechnology, India.

Project Title: Enhanced production, purification and characterization of marine bacterial lipopeptide as potential broad spectrum antimicrobial and anti cancer agent
Principal Investigator: Dr. Ramkrishna Sen
Co-Principal Investigator: Dr. Mahitosh Mandal
Sponsor: Ministry of Earth Science, India

Member of Professional Bodies

  • Associate Member : American Association for Cancer ResearchAssociate Member : American Society for Biochemistry and Molecular BiologyAssociate Member : Indian Association for Cancer Research
  • Associate Member : Indian Science Congress Association

Member, Editorial Board

  • Editorial Board Members : International Journal of BioSciences and Technology